Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones

Afaf E. G. Osman,Nuria Mencia-Trinchant,Caner Saygin,Luke Moma,Aelin Kim,Genevieve Housman,Matthew Pozsgai,Eti Sinha, Pooja Chandra,Duane C. Hassane,Andrea Sboner,Kishan Sangani,Nick DiNardi, Christopher Johnson,Sara S. Wallace,Bana Jabri,Hue Luu,Monica L. Guzman,Pinkal Desai,Lucy A. Godley

Blood Advances（2023）

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摘要

•CH can be confined to specific bone marrow spaces and may be eliminated through surgical extraction.•Patients with osteoarthritis have a high prevalence of CH, involving genes encoding epigenetic modifiers and DNA damage repair proteins.

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ch clones,bone marrow,peripheral blood samples

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