Novel grading system for CADASIL severity: A multicenter cross-sectional study

•page 14, paragraph 2. “Relying on clinical interviews or information documented in medical records for the assessment of cognitive status rather than formal cognitive testing may underestimate the prevalence and severity of cognitive impairment.”.•paragraph 3 on page 10. “Table 2 provides an overview of the radiographic findings observed in CADASIL patients from two clinical centers. The mean volume of white matter hyperintensities (WMH) for the entire cohort was determined to be 54.72 ± 33.8 ml. WMH volumes observed in patients with late-stage severity grades were not significantly higher than for patients with early-stage disease (58.35 ± 34.75 ml vs. 50.84 ± 32.93 ml, respectively; p = 0.402). Additionally, the average global cortical thickness across the entire cohort was found to be 2.06 ± 0.25 mm. An inclination towards thinner cortices was observed in patients with advanced severity grades, as early-stage patients had an average global cortical thickness of 2.07 ± 0.23 mm, while late-stage patients had 2.06 ± 0.26 mm (p = 0.830).”•page 9 paragraph 1 “The rationale for this categorization was implemented to address the potential of obtaining misleading outcomes due to the limited number of patients within certain severity grades (example, grade 3, n = 3).”.