Harnessing immunomodulation for efficient bone Regeneration: Bioengineered black phosphorus-incorporated Self-Healing hydrogel

Jinfeng Huang,Quan-Chang Tan,Hao Bai,Jing Wang,Pooyan Makvandi,Moonis Ali Khan,Xiaofan Hu,Zixiang Wu

Chemical Engineering Journal（2023）

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摘要

•TA-Mg2+ chelate on black phosphorus (BP) can prevent the fast oxidation of BP nanosheets.•SFMA–BP@TA-Mg hydrogel significantly improve macrophages polarize to M2 phenotype.•SFMA–BP@TA-Mg hydrogel enhanced osteogenesis and angiogenesis via immunomodulation and thus improved the new bone regeneration.

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关键词

efficient bone regeneration,hydrogel,harnessing immunomodulation,phosphorus-incorporated,self-healing

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