113. Static and Dynamic Functional Connectivity Changes From the Lateral Habenula Associate With Therapeutic Response to Ketamine Treatment in Major Depression

Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, produces fast-acting antidepressant effects in treatment resistant depression (TRD). Ketamine’s blockade of NMDAR bursting activity in the lateral habenula (LHb) improves depressive-like behavior in animal models. Here, we examined if serial ketamine infusion (SKI) treatment modulates static and dynamic functional connectivity between the LHb and other brain regions in TRD.