168. Personalised, Connectome-Based, Deep-Brain Stimulation Target-Informed Transcranial Magnetic Stimulation: A Proof-of-Concept Study

Deep-brain stimulation (DBS) generally improves treatment-resistant obsessive-compulsive disorder (OCD), modulating pathological neural activity of implantation site and connected brain-wide networks. However, its invasiveness, side-effects and lack of customisation, make non-invasive treatments preferable. We investigated whether the networks of effective OCD DBS targets (here subthalamic nucleus-STN and nucleus accumbens-NAc) can be modulated non-invasively with transcranial magnetic stimulation (TMS), as proof-of-concept for a potential standalone, or preparatory to DBS, treatment for refractory patients.