A novel oral biomimetic delivery system enhancing both the mucosal and systemic immunity of influenza virus vaccine

Hongyan Lu,Yikun Gao,Jianmin Chen, Jing Chai,Ansheng Li,Tongtong Sun,Yuling Mao,Ye He,Qinfu Zhao,Jinghai Zhang,Siling Wang

Chemical Engineering Journal（2023）

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摘要

•Mesoporous silica nanoparticles were customized for oral delivery of split vaccine.•Vaccine was delivered to mesenteric lymph nodes mainly via the IECs pathway.•Vaccine was delivered by simulating the metabolism process of dietary fat.

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关键词

Mesoporous silica nanocarrier,Oral vaccine,Mucosal and systemic immunity,Adjuvant,Influenza split vaccine,Intestinal lymphatic delivery

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