Clostridioides difficile infections were predominantly driven by fluoroquinolone-resistant Clostridioides difficile ribotypes 176 and 001 in Slovakia in 2018–2019

•A high proportion of epidemic ribotypes 001 and 176 (85%) were identified in Slovakia.•86% (n=318/370) of isolates were resistant to moxifloxacin by Thr82Ile in GyrA (99.7%).•Whole-genome sequencing of one isolate of predominant ribotype confirmed close genetic relatedness.•The erm(B) and aac(6′)-aph(2′') genes were frequently present in sequenced isolates.•Strains with cfr(E) (n=9) and cfr(C) (n=1) genes were linezolid susceptible.