Nanoengineering multifunctional extracellular vesicles availably mitigate bone loss in osteoporosis through binding to RANKL and rebalancing the Treg/Th17 cells

Zhengyu Yang,Zhen Yang,Lin Ding,Cong Liu,Fujian Zhao,Xiaofeng Chen,Chang Du

Chemical Engineering Journal（2023）

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摘要

•SrBGN + Mφ-EVs can competitively bind to RANKL and inhibits osteoclast activity.•SrBGN + Mφ-EVs can regulate the immune environment.•SrBGN + Mφ-EVs can inhibit bone loss through regulating Treg/Th17 balance in vivo.•This study provides new ideas to re-establish immune homeostasis in osteoporosis.•This study provides solutions for the treatment of bone resorption disorders.

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multifunctional extracellular vesicles,mitigate bone loss,osteoporosis,cells

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