509. Meta-Analysis of Functional Neuroimaging Studies of the Effects of Serotonergic Psychedelics on Neural Activity

There is an increasing interest toward the neural effects of psychedelic drugs due to their potential therapeutic benefits, particularly serotonergic psychedelics that act as 5-HT2A receptor agonists. However, their effects on neural activity in both clinical and healthy populations is not well understood. The present meta-analysis aims to advance our understanding of the most widely used serotonergic psychedelics – LSD, psilocybin, and MDMA – by examining their effects on the functional activation throughout the whole brain among both clinical and healthy participants.