Risk factors and clinical features associated with basal ganglia manganese deposition in patients with hereditary hemorrhagic telangiectasia

•T1-hyperintensity in the basal ganglia due to manganese deposition is a known finding in patients with hereditary hemorrhagic telangiectasia•However, the risk factors and clinical significance of these findings are unclear•Significant risk factors for deposition include increased age, iron deficiency anemia, hepatic AVMs, and liver cirrhosis•At a 3T field strength, significant associations were found between T1-hyperintensity and tremors, restless leg syndrome, and memory problems