Polymorphisms in Toll-Like receptors genes and their associations with immunological parameters in Plasmodium vivax malaria in the Brazil-French Guiana Border

•Cytokines: Cytokine levels contribute to clinical manifestations such as parasitemia, severity, and susceptibility in malaria infections.•MSP-119: No associations between SNPs studied of TLRs and antibody levels of MSP-1 were observed.•P. vivax: This is the predominant and spread worldwide malaria specie, despite an alarming number of people becoming infected each year, is still considered a neglected disease.•TLRs: Play a critical role in the innate immune response to malaria. They recognize specific parasite-derived molecules and initiate immune signaling pathways.•SNPs: In TLR genes play an important role in malaria pathogenesis and have been associated with susceptibility and parasitemia.