Heparinized PGA host-guest hydrogel loaded with paracrine products from electrically stimulated adipose-derived mesenchymal stem cells for enhanced wound repair

•Appropriate electrical stimulation could boost the paracrine function of adipose derived stem cells.•Heparinized host-guest PGA hydrogel loaded with paracrine factors could effectively benefit the process of wound repair through improving the overall local microenvironment at wound bed.•Our study highlighted the potential and possible value of organically combining electrical stimulation, paracrine products from ASCs and self-healing hydrogels for wound repair.