A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits: A congenital rat model

Marie Sønderstrup,Mykhailo Y. Batiuk,Panagiotis Mantas,Carles Tapias-Espinosa,Ignasi Oliveras,Toni Cañete,Daniel Sampedro-Viana,Tomasz Brudek,Rasmus Rydbirk,Konstantin Khodosevich,Alberto Fernandez-Teruel,Betina Elfving,Susana Aznar

European Neuropsychopharmacology（2023）

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摘要

•The RHA-I rat strain is a behavioral model presenting schizophrenia-like traits.•The RHA-I FC transcriptome shows differential expression of synaptic genes.•Co-expressed gene modules differentially expressed during infancy are enriched in adult RHA-I FC.•Cables1 is a gene related to synaptic maturation and underexpressed in adolescent RHA-I rats.•Alteration in synaptic gene regulation is manifested in adult RHA-I.

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关键词

frontal cortex,congenital maturational model,synaptic transcriptional landscape,maturational shift,schizophrenia-relevant

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