Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes

•CacyBP/SIP is expressed in human HaCaT keratinocytes.•CacyBP/SIP promotes epidermal differentiation.•Poly(I:C) treatment induces antiviral immune response in HaCaT cells.•CacyBP/SIP knockdown attenuates STAT1 signaling and expression of antiviral proteins.•CacyBP/SIP is involved in the antiviral response of human keratinocytes.