Schisandrin treatment suppresses the proliferation, migration, invasion, and inflammatory responses of fibroblast-like synoviocytes from rheumatoid arthritis patients and attenuates synovial inflammation and joint destruction in CIA mice

Wei Lin,Yingli Liu,Shuoyang Zhang,Siqi Xu,Qian Qiu,Cuicui Wang,Di Liu,Chuyu Shen,Meilin Xu,Maohua Shi,Youjun Xiao,Guoqiang Chen,Hanshi Xu,Liuqin Liang

International Immunopharmacology（2023）

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摘要

•SCH treatment suppresses FLS-mediated synovial inflammation and joint destruction of RA by targeting SREBF1.•Knockdown of SREBF1 controls the pathogenic behaviours of RA FLSs.

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关键词

Rheumatoid arthritis, Fibroblast-like synoviocytes, Schisandrin, SREBF1, NF-kappa B signalling pathway, AKT signalling pathway

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