GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures

•GKLF was involved in kainic acid-induced epileptic seizures.•GKLF increased KA-induced pro-inflammatory cytokine secretion in the hippocampus.•GKLF enhanced activation of NLRP3 inflammasomes and microglia in the hippocampus.•GKLF increased TXNIP transcription in LPS-activated microglia.•GKLF promoted activation of NLRP3 inflammasomes in microglia via TXNIP.