Role of chemokines in T-cell acute lymphoblastic Leukemia: From pathogenesis to therapeutic options

•Chemokines and their receptors play crucial roles in the infiltration and drug resistance mechanisms of T-ALL cells.•Chemokine receptors such as CCR4 and CCR8 exert significant effects on both T-ALL cells and immunosuppressive cells.•Chemokines and their receptors exert effects on various cellular components in diverse T-ALL microenvironments.•Further elucidation of chemokine biology may facilitate the development of targeted therapeutics of T-ALL.