High-Dose immunoglobulin Intervention as an effective and simple strategy for donor specific Anti-HLA antibody desensitization in haploidentical transplant

Jinye Zhu,Qian Wang, Yongjia Liu,Yujun Dong,Zeyin Liang,Yue Yin,Wei Liu,Weilin Xu,Yuhua Sun,Bingjie Wang,Qingyun Wang,Qingya Wang,Na Han,Hanyun Ren,Yuan Li

International Immunopharmacology（2023）

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摘要

•DSA with MFI over 5000 was related to poor engraftment.•IVIg was effective and simple for DSA desensitization.•Patients treated with IVIg exhibited similar engraftment, complications and survival with the DSA negative ones.

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关键词

Donor specific anti-HLA antibody, Desensitization, Immunoglobulin, Hematopoietic Stem Cell Transplantation, Engraftment

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