JAK2/STAT5 inhibition protects mice from experimental autoimmune encephalomyelitis by modulating T cell polarization

Yingying Wei,Zachary Braunstein,Jun Chen,Xinwen Min,Handong Yang,Lihua Duan,Lingli Dong,Jixin Zhong

International Immunopharmacology（2023）

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摘要

•Whole-body or T cell-specific deletion of JAK2 completely prevented EAE onset.•JAK1/2 inhibitor baricitinib alleviated EAE severity.•Selective JAK2 inhibitor fedratinib alleviated EAE severity.•Genetic deletion or pharmacological inhibition of JAK2 reduced TH1 differentiation.•JAK2 promoted TH1 polarization via STAT5/T-bet signaling.

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关键词

Experimental Autoimmune Encephalomyelitis,T cell,TH1,Multiple Sclerosis,JAK2,STAT5

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