The Clinical Significance and Biological Function ofDPEP1in B-cell Acute Lymphoblastic Leukemia

crossref(2019)

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摘要
AbstractDehydropeptidase-1 (DPEP1) is a zinc-dependent metalloproteinase abnormally expressed in many cancers. However, its potential role in adults with B-cell acute lymphoblastic leukaemia (ALL) is unknown.We found that in adults with common-B-cell ALL highDPEP1transcript levels at diagnosis was independently-associated with an increased CIR and worse RFS compared with subjects with low transcript levels. We show an increased proliferation and pro-survival role ofDPEP1in B-cell ALL cellsviaregulation of phosphCREB and p53 which may be the biological basis of the clinical correlation we report. Our data implicateDPEP1expression in the biology of common B-cell ALL in adults. We report clinical correlates and provide a potential biological basis for these correlations. If confirmed, analyzingDPEP1transcript levels at diagnosis could help predict therapy-outcomes. Moreover, regulation ofDPEP1expression could be a therapy target in B-cell ALL.
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