Polygenic risk for termination of the ‘healthspan’ and its interactions with lifestyle factors: A prospective cohort study based on 288,359 participants

•‘Healthspan’ is the number of years of living without any of seven severe aging-related morbidities.•There is no consensus on how lifestyle factors interact with genetic risk in their effects on longevity and health.•Healthy living can cut the risk of termination of the ‘healthspan’ by 40 %, even in the presence of high genetic risk.•Individuals at high genetic risk benefit more from healthy living.