Acyclic Enediynes Fused to Triazole and Benzothiophene Containing Propargylamine Moieties

Synthesis of 3-(5-triazolyl)- and 3-(3-benzothienyl)-propargylamines includes the Mannich reaction of the corresponding ethynyl derivatives with diaminomethanes. The MTT test of the synthesized compounds toward the viability of NCI-H460 lung carcinoma cells and WI-26 VA4 normal lung fibroblast cells reveals one of them possessing a notable cytotoxic activity.