Real world evidence study of Danish patients with Fabry disease: A 20-year longitudinal retrospective analysis of prospectively collected data

In commonly studied gold(I) complexes with oligo (o-, p-, or m-phenyleneethynylene) (PE) ligands, an intriguing photophysical behavior is dual emission composed of fluorescence from S1 and phosphorescence from T1 which is dictated by effective intersystem crossing (ISC) process. In order to explore the salient photodynamics of such oligo-PE gold(I) complexes effectively, we have deliberately chosen three model complexes, namely, PhCCAu(PMe3) (1a′) and PhCC(1,m)C6H4CCAu(PMe3) (m = 4, 2a′; m = 3, 3a′) in place of the real system. Firstly, electronic structure methods based on DFT and TD-DFT are utilized to perform optimization calculations for the ground- and lowest-lying excited states, respectively. Next, basic photophysical properties including absorption and emission spectra are investigated by TD-DFT under the optimized geometries. Besides, on the basis of the electronic spectra herein, we succeed in searching for surface intersections as the minima on the seam of singlet–triplet surface crossings (SCs) at the CASSCF level of theory. By integration of the results available, the process of delayed fluorescence of triplet–triplet annihilation (TTA) and phosphorescence was displayed in detail with SCs playing the lead in monitoring the ISC.