Targeting MYC in combination with epigenetic regulators induces synergistic anti-leukemic effects in MLLr leukemia and simultaneously improves immunity

Rahel Fitzel, Kathy-Ann Secker-Grob,Hildegard Keppeler,Fulya Korkmaz,Rebekka Schairer,Estelle Erkner,Dominik Schneidawind,Claudia Lengerke,Thomas Hentrich,Julia M. Schulze-Hentrich,Corina Schneidawind

Neoplasia（2023）

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摘要

MLL rearranged (MLLr) leukemias are associated with a poor prognosis and a limited response to conventional therapies. Moreover, chemotherapies result in severe side effects with significant impairment of the immune system. Therefore, the identification of novel treatment strategies is mandatory.

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