Personalized estimates of morphometric similarity in multiple sclerosis and neuromyelitis optica spectrum disorders

Jie Sun, Wenjin Zhao,Yingying Xie,Fuqing Zhou,Lin Wu,Yuxin Li,Haiqing Li,Yongmei Li,Chun Zeng,Xuemei Han,Yaou Liu,Ningnannan Zhang

NeuroImage: Clinical（2023）

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摘要

•PBSI shows quantifiable brain structural heterogeneity correlations in MS and NMOSD.•Six multi-center datasets validation for PBSI measurements at group level.•MS showed a greater neuroanatomical heterogeneity pattern than NMOSD.•MS and NMOSD exhibit different brain regions that may drive disease heterogeneity.•MS and NMOSD show age stage-dependency of neuroanatomical heterogeneity.

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关键词

Multiple Sclerosis,Neuromyelitis optica spectrum disorders,Person-based similarity index,Cortical thickness,Subcortical volume

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