Small Molecule Inhibition of Glycogen Synthase 1 Restores Autophagolysosomal and Metabolic Pathway Dysfunction in a Mouse Model of Pompe Disease

In this study, the potential of chitosan/poly(vinyl alcohol) (CS/PVA) blends as capping agent for stabilization of Ag-nanoparticles (Ag NPs) during their in situ gamma irradiation induced synthesis was investigated. The UV–vis absorption spectra show the surface plasmon absorption band around 410 nm, which confirms the formation of Ag-nanoparticles. It was found that the composition of CS/PVA blend affected the size of the obtained Ag-nanoparticles, as well as the parameters such as density, molar concentration and effective surface area, calculated from the experimentally obtained UV–vis absorption spectra and spectra obtained by simulation according to the Mie theory. SEM micrograph and XRD measurement indicated a spherical morphology and face centered cubic crystal structure of Ag-nanoparticles, with diameter around 12 nm. The values of optical band gap energy between valence and conduction bands (Eg), calculated from the UV–vis absorption spectra, also show dependence on the blend composition for Ag–CS/PVA colloids as well as for Ag–CS/PVA nanocomposites.