Intra-articular mm-ii, a novel suspension of large empty multilamellar liposomes, in painful knee osteoarthritis: a 26 week phase 2b placebo-controlled double blind randomized trial
Osteoarthritis and Cartilage(2023)
摘要
Purpose: Additional safe and effective therapies are needed for osteoarthritis (OA) pain. MM-II, a novel suspension of empty large multilamellar liposomes composed of dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC), has been shown to have beneficial effects in OA animal models. In a previously reported first-in-man study, a single intra-articular injection of MM-II demonstrated lower pain in knee OA patients for up to 3 months. The aim of the current phase 2b study was to determine an effective dose of MM-II, durability of response through 26 wks, and safety of MM-II in patients with symptomatic knee OA.
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关键词
large empty multilamellar liposomes,painful knee osteoarthritis,intra-articular,placebo-controlled
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