The Chinese herbal KangXianYiAi formula inhibits hepatocellular carcinoma by reducing glutathione and inducing ferroptosis

Xiaobin Zao,Xu Cao,Yijun Liang,Jiaxin Zhang,Hening Chen,Ningyi Zhang,Ruijia Liu,Qian Jin,Yue Chen,Xiaoke Li,Hongbo Du,Guang Chen,Li Hou,Yong'an Ye

Pharmacological Research - Modern Chinese Medicine（2023）

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摘要

•Traditional Chinese medicine KXYA formula exerted an anti-HCC effect in vivo and in vitro.•Omics detection and experimental verification showed that KXYA inhibited HCC by reducing glutathione and inducing ferroptosis.•The key targets of KXYA treatment on HCC were UGDH, AKR1B10, and SLC7A11, which could be the therapeutic targets for HCC.

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关键词

chinese herbal kangxianyiai formula,hepatocellular carcinoma,glutathione

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