Evaluation of solid-lipid nanoparticles formulation of methotrexate for anti-psoriatic activity

Debarati Maiti,Mohammed Naseeruddin Inamdar,Mansour Almuqbil,Sarasija Suresh,Syed Mohammed Basheeruddin Asdaq,Sultan Alshehri,Saad Ali Al Arfaj,Ali Musharraf Alamri, Meshal Meshary Aldohyan, Misfir Theeb Alqahtani, Turki Mohammed Alosaimi, Sami Haran Alenazi, Moneer E. Almadani,Jameel Ahmed S. Mulla,Syed Imam Rabbani

Saudi Pharmaceutical Journal（2023）

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摘要

The findings suggested that MTX in solid-lipid nanoparticles could be a promising formulation for the management of psoriasis since the drug was slowly released, progressively inhibited the growth of keratinocytes, and distributed mostly in organs meant for elimination. More studies in this direction might establish the precise safety and efficacy of SLN-MTX formulation in psoriasis.

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关键词

methotrexate,nanoparticles,solid-lipid,anti-psoriatic

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