Myracrodruon urundeuva lectins present anticancer and anticryptococcal activities with low cytotoxic or genotoxic effects

Larissa Cardoso Corrêa de Araújo Videres,Matheus Cavalcanti de Barros,Thamara Figueiredo Procópio, Gustavo Ramos Salles Ferreira,Pollyanna Michelle da Silva,André Mariano Batista,Maria Madalena Pessoa Guerra,Marilene Henning Vainstein,Jaciana dos Santos Aguiar,Thâmarah de Albuquerque Lima,Thiago Henrique Napoleão,Teresinha Gonçalves da Silva,Patrícia Maria Guedes Paiva

South African Journal of Botany（2023）

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摘要

•M. urundeuva lectins were potentially toxic to human lymphocytes and non-hemolytic.•M. urundeuva lectins showed weak genotoxicity to human lymphocytes.•MuHL and MuLL were moderately active against cancer cell lines.•MuHL non-cytotoxic or genotoxic doses were fungicidal against Cryptococcus.•MuHL acted synergistically with fluconazole and inhibited C. neoformans biofilm.

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anticryptococcal activities,present anticancer

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