An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography.

This individual patient data meta-analysis on 8 international cohorts including 798 patients demonstrated that MRE achieves excellent diagnostic accuracy for significant, advanced fibrosis and cirrhosis in patients with NAFLD. The cut-off values (significant fibrosis: 3.14 kPa, advanced fibrosis: 3.53 kPa, cirrhosis: 4.45 kPa) were established. Elevated inflammatory activity and GGT level may affect the diagnostic accuracy of MRE, overestimating liver fibrosis in early stages. No impact of diabetes, obesity or any other metabolic disorder on the diagnostic accuracy of MRE.