Flipping the script: defining the reversibility of platelet activation.

The conventional model of platelet activation is that it moves in 1 direction; a quiescent platelet becomes an activated platelet. However, can an activated platelet become a quiescent platelet? More precisely, can a previously activated platelet be reactivated or participate in hemostasis? In this issue of the Journal of Haemostasis and Thrombosis, De Simone et al. [ [1] De Simone I. Baaten C.C.F.M.J. Gibbins J.M. ten Cate H. Heemskerk JWM, Jones CI, van der Meijden PEJ. Repeated platelet activation and the potential of previously activated platelets to contribute to thrombus formation. J Thromb Haemost. 2023; 21: 1289-1306 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar ] have provided new insight into the reversibility of platelet activation.