Uncoupling CD4+ TIL-mediated tumor killing from JAK-signaling in melanoma.

Arianna Draghi,Mario Presti,Agnete W P Jensen,Christopher A Chamberlain,Benedetta Albieri, Anne-Christine K Rasmussen,Mads H Andersen,Michael D Crowther,Inge Marie Svane,Marco Donia

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

In conclusion, our data indicate that exploiting tumor-specific cytotoxic CD4+ TILs could help overcome resistance to ICB mediated by IFNγ-signaling loss in MHCIIconst+ melanomas.

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