Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease.

Mark L Derbyshire, Sruti Akula, Austin Wong, Karisa Rawlins,Evelyn B Voura,William J Brunken,Michael E Zuber,Sabine Fuhrmann,Anne M Moon,Andrea S Viczian

Investigative ophthalmology & visual science（2023）

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摘要

To the best of our knowledge, these studies are the first demonstration that Tbx3 is required for normal mammalian eye formation. Together, the results provide a potential genetic model for retinal hypovascular diseases.

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关键词

retinopathy of prematurity, angiogenesis, conditional knockout, Tbx3, retinal ganglion cells

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