Association of serum neurofilament light with microglial activation in multiple sclerosis.

Maija Saraste,Markus Matilainen,Anna Vuorimaa,Sini Laaksonen,Marcus Sucksdorff,David Leppert,Jens Kuhle,Laura Airas

Journal of neurology, neurosurgery, and psychiatry（2023）

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摘要

Our demonstration of an association between microglial activation as measured by increased TSPO-PET signal, and elevated sNfL emphasises the significance of smouldering inflammation for progression-promoting pathology in MS and highlights the role of rim-active lesions in promoting neuroaxonal damage.

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serum neurofilament light,microglial activation,multiple sclerosis

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