High Recurrence for HPV-Positive Oropharyngeal Cancer With Neoadjuvant Radiation Therapy to Gross Disease Plus Immunotherapy: Analysis From a Prospective Phase Ib/II Clinical Trial.

Ting Martin Ma,Deborah J Wong,Wanxing Chai-Ho,Abie Mendelsohn,Maie St John,Elliot Abemayor,Dinesh Chhetri,Dipti Sajed,Audrey Dang,Fang-I Chu,Michael Xiang,Ricky Savjanji,Joanne Weidhaas,Michael L Steinberg,Minsong Cao,Amar U Kishan,Robert K Chin

International journal of radiation oncology, biology, physics（2023）

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摘要

Neoadjuvant SBRT delivered only to the gross tumor before surgery is associated with a high early risk of lymph node recurrence in HPV+ OPSCC despite concurrent/adjuvant immunotherapy. The results caution against omitting elective volume irradiation even in this group of patients with relatively favorable prognosis.

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