Neurocognitive functioning in COMISA patients is better after PAP therapy, but worse after CBT-I: Exploratory analysis of Cognitive Outcomes from the MATRICS Study.

Treatment combinations involving CBT-I were associated with poorer neurocognitive performance. These potentially temporary effects may stem from sleep restriction, a component of CBT-I often accompanied by initially reduced total sleep time. Future studies should examine long-term effects of individual and combined COMISA treatment pathways to inform treatment recommendations.