The metabolic pathways and products of ten Aconitum alkaloids in Sanwujiao Pills from eight organs of mice by UHPLC-Q-TOF-MS/MS.

Wen-Han Pei,Yu-Feng Huang,Ying Xie,Yuan Qu,Fan He,Hua Zhou

Current drug metabolism（2023）

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摘要

This is the first report about the metabolism of ten AAs in SWJPs in mice. Significantly, the metabolic pathways and products of four hidden toxic AAs were analyzed in vivo for the first time. The results were of great significance for the safety and effectiveness of SWJPs in clinical application.

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