DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma.

Hyo In Kim,Jinbong Park,David Gallo,Sidharth Shankar,Barbora Konecna,Yohan Han,Valerie Banner-Goodspeed,Krystal R Capers,Seong-Gyu Ko,Leo E Otterbein,Kiyoshi Itagaki,Carl J Hauser

Annals of surgery（2023）

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摘要

Tissue injury-derived DAMPs suppress antimicrobial immunity via canonical GRK2 activation and a novel TLR-activated GRK2 pathway impairing cytoskeletal organization. Simultaneous GRK2/HDAC inhibition rescues susceptibility to infection after tissue injury.

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