Local Multiple-site Injections of a Plasmid Harboring Human MnSOD Mitigate Radiation-induced Skin Injury by Inhibiting Ferroptosis.

Xiaoying Wang,Yuxin Lu,Xiaochen Cheng,Xuefeng Zhu,Dujuan Li,Haiying Duan, Shenhui Hu,Fengjun Xiao,Li Du,Qinglin Zhang

Current drug delivery（2023）

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摘要

The present study provides evidence that the protective effects of MnSOD in irradiated HaCaT cells may be related to the inhibition of ferroptosis. The multi-site injections of pMnSOD had clear therapeutic and preventive effects on radiation-induced skin injury in rats. pMnSOD may have therapeutic value for the treatment of radiation-induced skin injury.

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