Paraconulones A-G: Eremophilane Sesquiterpenoids from the Marine-Derived Fungus Paraconiothyrium sporulosum DL-16.

Seven new eremophilane sesquiterpenoids, paraconulones A-G (-), along with three previously reported analogues, periconianone D (), microsphaeropsisin (), and 4--microsphaeropsisin (), were obtained from an EtOAc extract of the marine-derived fungus DL-16. The structures of these compounds were elucidated by extensive spectroscopic and spectrometric analyses, single-crystal X-ray diffraction, and computational studies. Compounds , , and are the first examples of dimeric eremophilane sesquiterpenoids coupled through a C-C bond identified from microorganisms. Compounds -, , and showed inhibitory effects on lipopolysaccharide-induced NO production in BV2 cells, which were comparable to the positive control curcumin.