FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways.

Garima Dixit,Jesus Gonzalez-Bosquet,Joseph Skurski,Eric J Devor,Erin B Dickerson,Warren B Nothnick,Priya D Issuree,Kimberly K Leslie,Thorsten Maretzky

Clinical and translational medicine（2023）

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摘要

These findings highlight a pivotal role of ADAM17 in the pathogenesis of EC and provide a compelling rationale for targeting ADAM17 protease activity in FGFR2-driven cancers.

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关键词

a disintegrin and metalloprotease 10, a disintegrin and metalloprotease 17, endometrial cancer, epidermal growth factor receptor, fibroblast growth factor receptor 2, Notch

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