Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer.

Chi-Son Chang,Ji-Yoon Ryu,June-Kuk Choi,Young-Jae Cho,Jung-Joo Choi,Jae Ryoung Hwang,Ju-Yeon Choi,Joseph J Noh,Chan Mi Lee,Ji Eun Won,Hee Dong Han,Jeong-Won Lee

Journal of gynecologic oncology（2023）

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摘要

FZ-incorporated PLGA nanoparticles exerted significant anti-cancer effects in EOC cells and xenograft models including PDX. These results warrant further investigation in clinical trials.

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关键词

Fenbendazole, Epithelial Ovarian Cancer, PLGA Nanoparticle, Patient-Derived Xenograft, Drug Repurposing

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