Natural Polymer-based Thin Film Strategies for Skin Regeneration in lieu of Regenerative Dentistry.

Wound healing is a complex and dynamic process that comprises of a series of molecular and cellular events that occur after tissue injury. The injuries of the maxillofacial and oral region caused by trauma or surgery result in undesirable wound healing such as delayed wound closure and formation of scar tissue. Skin tissue engineering/regeneration is an emerging approach towards faster, superior, and more effective resolution of clinically significant wounds effectively. A multitude of tissue engineering principles approaches are being put to action for the fabrication of hydrogels, electrospun sheets, 3D scaffolds, and thin films that can be used as wound dressings materials, sutures, or skin substitutes. Thin films are advantageous over other materials owing to their flexibility, ability to provide a barrier against external contamination, easy gaseous exchange and easy monitoring of wounds. This review focuses on wound-dressing films and their significance and discusses various fabrication techniques. Additionally, we explore various natural biopolymers that can be used for fabrication of skin tissue engineering materials.