Multifactorial estimation of clinical outcome in HPV-associated oropharyngeal squamous cell carcinoma via automated image analysis of routine diagnostic H&E slides and neural network modelling.

Oral oncology(2023)

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摘要
Our open-source H&E analysis workflow and predictive models confirm previously reported prognostic features and identifies novel factors which predict HPV + OpSCC outcomes with promising accuracy. Our work supports the use of machine learning in digital pathology to exploit clinically relevant features in routine diagnostic pathology without additional biomarkers.
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关键词
Human papillomavirus, Oropharyngeal squamous cell carcinoma, Oropharyngeal cancer, Oral and maxillofacial pathology, Head and neck cancer, Computer-assisted image analysis, Machine learning, Neural network models, Tumor microenvironment, Single-cell analysis
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