Triptolide alleviates collagen-induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN-STAT3 pathway.

Yao Huang,Xin Ba,Hui Wang,Pan Shen,Liang Han,Weiji Lin,Jiahui Yan,Zhe Chen,Shenghao Tu

Basic & clinical pharmacology & toxicology（2023）

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摘要

TP can inhibit inflammation and alleviate bone destruction in CIA mice. The underlying mechanism is related to the regulation of the imbalance of Treg/Th17 cells through the JAK/PTEN-STAT3 pathway.

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关键词

collagen-induced arthritis, reverse docking, STAT3, Th17 cells, Treg cells, triptolide (TP)

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