Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy.

Zongzhi Liu,Xiang Li,Yibo Gao,Jiejie Liu, Yating Feng,Yang Liu,Junyun Wang,Chunmeng Wang,Dongrui Wang,Jie He,Weidong Han,Qian Mei,Yingli Sun

Molecular cancer（2023）

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摘要

We demonstrate that the DNA methylation of Runx3 plays a critical role in CD8+ T-cell infiltration and differentiation during decitabine-primed PD-1-ab immunotherapy, which provides a supporting mechanism for the essential role of epiregulation in immunotherapy.

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关键词

epigenetic reprogramming,t-cell

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