Long-Term Benefit of Perlingual Polybacterial Vaccines in Patients with Systemic Autoimmune Diseases and Active Immunosuppression.

Inés Pérez-Sancristóbal,Eduardo de la Fuente, María Paula Álvarez-Hernández,Kissy Guevara-Hoyer,Concepción Morado,Cristina Martínez-Prada,Dalifer Freites-Nuñez,Virginia Villaverde,Miguel Fernández-Arquero,Benjamín Fernández-Gutiérrez,Silvia Sánchez-Ramón,Gloria Candelas

Biomedicines（2023）

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摘要

Even though the beneficial protective effects against infections of TIbV progressively decreased, they remained low for up to 3 years, with significantly reduced infections compared to the year prior to vaccination, further supporting a long-term benefit of TIbV in this setting. Moreover, an absence of infections was observed in almost half of patients.

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trained-immunity-based vaccines, recurrent infections, systemic autoimmune disease prophylaxis, cohort study

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