Evaluation of 2D and 3D Erythroid Differentiation Protocols Using Sickle Cell Disease and Healthy Donor Induced Pluripotent Stem Cells.

Gabriele Louise Soares Martins,Carolina Kymie Vasques Nonaka,Erik Aranha Rossi, Adne Vitória Rocha de Lima,Corynne Stephanie Ahouefa Adanho, Moisés Santana Oliveira,Setondji Cocou Modeste Alexandre Yahouedehou, Clarissa Lima E Moura de Souza,Marilda de Souza Gonçalves,Bruno Diaz Paredes,Bruno Solano de Freitas Souza

Cells（2023）

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摘要

A robust 3D protocol for erythroid differentiation was identified using SCD-iPSCs and comparative analyses; however, the maturation step remains challenging and requires further development.

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关键词

sickle cell disease, erythropoiesis, iPSCs

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