scRNA-seq and proteomics reveal the distinction of M2-like macrophages between primary and recurrent malignant glioma and its critical role in the recurrence.

Guiting You, Zhenyu Zheng, Yulong Huang,Guifen Liu, Wei Luo,Jianhuang Huang, Longjin Zhuo,Binghua Tang,Shunyi Liu,Caihou Lin

CNS neuroscience & therapeutics（2023）

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摘要

Our study uncovers the distinction of M2-like TAMs between primary and recurrent glioma, which offers unparalleled insights into the immune microenvironment of primary and recurrent malignant glioma.

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关键词

immune microenvironment, intercellular interaction, recurrent malignant glioma, single-cell RNA sequencing, tumor-associated macrophages

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